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Male Birth Control: Why We Don’t Have It, And When We Might

Not every man wants to be a father and not every father wants more kids. Roughly half of all pregnancies in the United States are unintended. But when it comes to male birth control, none of the options are ideal and safe, reversible hormonal male contraception may be 10 years away.

Michael Skinner.
Skinner

But why has it taken this long? Why is there another decade to go? What barriers to male birth control still exist?

“Females only ovulate once per month, so it’s relatively easy to block with an endocrine approach,” Michael K. Skinner, director of the Center for Reproductive Biology at Washington State University told Fatherly. “Males produce millions of sperm daily…it’s difficult to design endocrine approach without shutting down all of male endocrinology.” In other words, in order to impact sperm production meaningfully, hormonal therapy would need to all but shutter the endocrine system—with serious side effects.

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Fatherly

With 86% Drop, California’s Monarch Butterfly Population Hits Record Low

They arrive in California each winter, an undulating ribbon of orange and black. There, migrating western monarch butterflies nestle among the state’s coastal forests, traveling from as far away as Idaho and Utah only to return home in the spring.

This year, though, the monarchs’ flight seems more perilous than ever. The Xerces Society for Invertebrate Conservation, a nonprofit group that conducts a yearly census of the western monarch, said the population reached historic lows in 2018, an estimated 86 percent decline from the previous year.

Cheryl Schulz.In a 2017 study, scientists estimated that the monarch butterfly population in western North America had a 72 percent chance of becoming near extinct in 20 years if the monarch population trend was not reversed. One of the study’s researchers, Cheryl Schultz, an associate professor of biology at Washington State University Vancouver, said at the time that an estimated 10 million monarchs spent the winter in coastal California in the 1980s.

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Dr. Universe: Why do we have five fingers and five toes?

While humans may be one of the few animals that can give a high five, they are one of many with five fingers and toes.

Humans are part of the primate family, which also includes monkeys, apes, and even lemurs. As a member of the family, you also have fingernails instead of claws and pads on your fingertips that help with your sense of touch.

Sian Ritchie.
Ritchie

We actually see a total of ten fingers and toes in a lot of other vertebrates – animals with backbones. Fossil evidence of some early vertebrates show that some creatures had six, seven, or even eight fingers. That’s what I found out from my friend Sian Ritchie, who teaches biology at Washington State University.

Ritchie told me how animals tend to keep the characteristics or traits that help them survive in an environment. These are called adaptations. They may also over time lose some traits, like a finger or two.

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Dr. Universe

Expanding research communities and collaborations

From the depths of ocean dead zones, to wide swaths of forests, and rising up to the troposphere, where most weather changes occur, the U.S. Department of Energy Joint Genome Institute (DOE JGI) 2014 Community Science Program portfolio seeks to parse functional information extracted from complex ecosystems to address urgent energy and environmental challenges. These massive, data-intensive undertakings require interdisciplinary approaches, many leveraging additional expertise through a new inter-DOE-Facility partnership.

Reflecting its vision of serving the scientific community as a next-generation genome science user facility, the DOE JGI has joined forces with the Environmental Molecular Sciences Laboratory (EMSL) at the Pacific Northwest National Laboratory to provide complementary scientific resources to significantly expand genomic understanding to cellular function. The inaugural round of eight accepted proposals showcases the synergy between these two DOE user facilities.

Five of the eight new DOE JGI-EMSL proposals going forward will focus on carbon cycling and three relate to improvements in biofuels production. Each of these projects will tap the capabilities at both facilities to further the research in ways that would not otherwise be possible, and all are targeted for completion within an 18-month time window.

Matthias Hess.
Hess

Two of the carbon cycling projects involve the study of cyanobacteria. Matthias Hess, research scientist and arts and sciences alumnus at Washington State University-Tri Cities, will build off the DOE JGI’s pioneering work in filling in gaps in the tree of life through the Genomic Encyclopedia of Bacteria and Archaea (GEBA) pilot project and a recent spin-off focused specifically on cyanobacteria.

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Bio-Medicine

Genetic mutation drives tumor regression in Tasmanian Devils

Andrew Storfer.
Andrew Storfer

Washington State University scientists, led by Andrew Storfer, an evolutionary geneticist and WSU professor of biology, have discovered genes and other genetic variations that appear to be involved in cancerous tumors shrinking in Tasmanian devils.

Their research is an important first step towards understanding what is causing devil facial tumor disease, a nearly 100 percent fatal and contagious form of cancer, to go away in a small percentage of Tasmanian devils and could have implications for treating cancer in humans and other mammals as well.

Mark Margres.
Mark Margres

“Some of the genes we think have a role in tumor regression in Tasmanian devils are also shared by humans,” said Mark Margres, a former WSU postdoctoral researcher now at Clemson University who is part of an international team of researchers studying devil facial tumor disease led by Storfer.

“While still in a very early stage, this research could eventually help in the development of drugs that elicit the tumor regression response in devils, humans and other mammals that don’t have this necessary genetic variation,” Margres said.

For the last decade, Storfer’s team has been investigating how some Tasmanian devil populations are evolving genetic resistance to devil facial tumor disease that could help the species avoid extinction.

Tasmanian devils have been pushed to the brink of extinction by the rapid spread of devil facial tumor disease, one of only four known forms of transmissible cancer and by far the deadliest. Since it was first documented in 1996, the disease has wiped out an estimated 80 percent of devils in Tasmania, the only place in the world where the animals live.

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